The Institute of Biomedical Sciences (IBMS) at NSYSU was established in 1999 with the mission to prepare students to fully engage and actively participate in all areas of the exciting and rapidly expanding field of biomedical sciences. Research is an integral part of teaching at IBMS, NSYSU. Faculty members share their research findings in the classroom, so students can learn first-hand about scientific discovery while working with professors in the laboratory. During the past decades, infrastructures including the accessibility of a large number of E-Journals in NSYSU library through the internet, and the core facility equipping a series of precision instruments at IBMS, which both are essential for biomedical research (cellular, molecular biology, genomics and proteomics, etc), have been well established. Our institute moreover preserves quite a few hardcopy literatures from earlier ages without E-Journals available. The MOST core laboratory founded at NSYSU further brings in new research resources and provides an easy-to-access principle for our students.
Abnormalities of genetic content/modifications and gene expression levels have been linked to many diseases, such as cancer. With the development of genome-wide technologies, we can identify disease-driving genes (or biomarkers) involved in the pathogenesis pathway(s) in a robust format from DNA to the protein levels. These novel technologies speed up the process of new target discovery and new drug development. With the working experiences at both academic and industrial organizations, Dr. Sheu’s research team aims to develop new treatments for biomedical applications.
Research Field: cancer genomics, chromatin remodeling, cytoskeleton, cell adhesion/migration, mechanotransduction, complementary & alternative medicine, antibody/vaccine engineering
Cellular architecture is well maintained and organized by cytoskeleton proteins that provide necessary mechanical support for various cellular functions. Recent findings reveal their involvement in mechano-transduction and the associated stem cell reprogramming. Through genome-wide sequencing, we discovered novel KFs in oral squamous cell carcinoma (OSCC) and the adjacent normal counterpart, suggesting KFs as possible drivers in OSCC development. KFs can compete with wild-type keratin and disturb the keratin network in cancer cells. Such alteration has huge impacts on the mechanical properties of cancer cells, resulting in loss of cell-cell contact inhibition, EMT transition, nuclear deformation, metabolic adaptation and microenvironement modeling.
RB is one of the most multifaceted and energy-demanding processes in cells, thus, it tightly control cellular growth and proliferation. Recently, RB up-regulation has been identified in endometriosis lesions and such machinery can be even hyper-activated during malignant transition from endometriosis to clear cell ovarian cancer. Since most of the current treatments have unwanted side-effects and do not cure the condition, it is therefore interesting to study whether blocking RB with specific inhibitors may provide a new and novel strategy for treating this debilitating disorder.PDF